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艾乐美生物科技有限公司(AllerMAbs Co., Ltd.)成立于2015年,是台湾一家专注于生产高亲和力、高纯度并具有过敏原特异性的嵌合人类IgE单克隆抗体的生物公司。公司创办人团队在科研过程中发现市面上缺乏多样的IgE单克隆抗体,特別是具有过敏原特异性的人IgE 单抗。如果能制备出这种抗体,将有助于IgE 相关领域的研究工作。因此,AllerMAbs公司团队开始思考与研究利用基因克隆动物来制造人类 IgE 抗体的可行性,经过数年的努力于 2014年开发出人类IgE 抗体基因嵌入小鼠,通过杂交瘤技术 (Hybridoma technology),成功地研制出分泌嵌合人类IgE 单抗的 IgE 杂交瘤与纯化 IgE 抗体。经测试,此种嵌合人类IgE 单抗的物化性质与对免疫细胞的活性,皆与人类IgE 抗体一致,研究成果于2015 年发表在国际学术期刊上。

 

AllerMAbs的产品解决了目前人类IgE抗体不易制备的问题,让嵌合人类IgE抗体可以成为人类IgE抗体的替代品,并提供一个更稳定、更符合血清IgE检测系统的校正品,让临床血清IgE的检测结果更加准确与可靠。

 

其利用动物基因转殖技术,将组成人类IgE抗体分子的ε重链(Heavy chain)和κ轻链(Light chain)的编码基因(Encoding genes),分別嵌入(Knock-in)小鼠胚胎干细胞(Embryonic stem cells, ES cells)的γ1重链和κ轻链基因的位置,接着把胚胎干细胞分別植入孕母鼠体内,并将其带有嵌入基因之成鼠交互配种,最后得到带有人类IgE抗体重链和轻链基因的基因嵌入小鼠(HεκKI mice),且体内能制造完整的嵌合人类IgE抗体分子。

 

技术优势

容易制备IgE杂交瘤与IgE单抗

过敏原特异性

良好的亲和力与专一性

高纯度与高稳定性

可结合至嗜碱性粒细胞上的IgE受体与刺激細胞

可大量生产与高浓度制备

非人类血液来源(相较于血清IgE抗体)

适合用作检测用的校正品

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艾美捷科技有限公司代理Verichem Laboratories公司标准品/校准液产品:

http://www.amyjet.com/Index/lists/catid/99/kid/56.html


产品名称规格
Ammonia/Iron Standard Kit (Verichem Laboratories; CAT#9040)5x15mL
Ammonia/Iron Standard Level F (Verichem Laboratories; CAT#9046)1x15mL
Bilirubin Standard Kit (Verichem Laboratories; CAT#9450)10x5mL
Bilirubin Standard, Level F (Verichem Laboratories; CAT#9436)2x5mL
Tru-Zero™ Bilirubin Standard (Verichem Laboratories; CAT#9456)2x5mL
Br2 Bilirubin Calibrator (Verichem Laboratories; CAT#9459)2x5mL
Carbon Dioxide Standard Kit (Verichem Laboratories; CAT#9210)5x15mL
Carbon Dioxide Standard, Level F (Verichem Laboratories; CAT#9216)1x15mL
Electrolyte Standard Kit (Verichem Laboratories; CAT#9200)5x15mL
Enzyme Er™ Verifier Kit (Verichem Laboratories; CAT#9410)6x5mL
Enzyme Er™ Verifier, Level G (Verichem Laboratories; CAT#9417)1x5mL
Ethanol Standard Kit (Verichem Laboratories; CAT#9670)6x5mL
Hdl Cholesterol Verifier Kit (Verichem Laboratories; CAT#9560)6x5mL
Matrix Plus™ Chemistry Reference Kit (Verichem Laboratories; CAT#9500)5x15mL
Matrix Plus™ Chemistry Reference, Level F (Verichem Laboratories; CAT#9506)1x15mL
Matrix Plus™ Cholesterol Reference Kit (Verichem Laboratories; CAT#9550)5x15mL
Matrix Plus™ Cholesterol Reference, Level F (Verichem Laboratories; CAT#9556)1x15mL
Microprotein Standard Kit (Verichem Laboratories; CAT#9480)5x15mL
Serum Ise Standard Kit (Verichem Laboratories; CAT#9240)5x15mL
Total Protein / Albumin Standard Kit (Verichem Laboratories; CAT#9460)5x15mL
Total Protein / Albumin Standard, Level F (Verichem Laboratories; CAT#9466)1x15mL
Urine Chemistry Standard Kit (Verichem Laboratories; CAT#9000)5x15mL
Urine Uric Acid Standard Kit (Verichem Laboratories; CAT#9020)5x5mL



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艾美捷科技代理Innovative Biochips品牌全系列产品


Innovative Biochips是休斯顿德克萨斯医学中心(TMC)的衍生公司,专注于开发先进的微流控技术,以尖端的灵敏度和高通量解决传统生物技术面临的难题。科研团队和工程师在为各类生物和生物医学应用开发新型微流体技术方面积累了的经验。通过不断创新和优化技术,Innovative Biochips为生命科学研究提供了更精准的工具,推动生物医学领域的进步。主要产品包括单细胞克隆分析、单细胞成像和配对、球状细胞培养等。


▍Innovative Biochips公司产品线

● 单细胞PCR与测序技术:本系列产品融合标准设备制式与创新微流控设计,提供多种简易、快速、经济的单细胞分离方案:实现单细胞向超微量液体环境的高效转移;完美适配单细胞裂解、PCR及测序等遗传分析流程。

● 单细胞克隆:在重组蛋白生产、基因功能研究与药物筛选中应用广泛。1CellPlate®-96孔超微量微流控板采用标准96孔板规格,结合独特的"孔中孔"微流控设计,为癌细胞、杂交瘤细胞、CHO细胞、CRISPR编辑细胞及干细胞等稳定细胞株开发,提供前所未有的简易单细胞分离方案。

● 单细胞检测:1CellPlate®-Assay 超低体积 96 孔微流控微孔板结合了超小孔和微流控网络,满足了单细胞细胞因子检测的需求。单细胞分泌的细胞因子可被收集并通过质谱进行深度分析。此外,具有显著高细胞因子分泌量的单细胞,也能通过常规移液器轻松回收,用于包括克隆或 PCR 测序在内的下游分析。

● 自动化寿命检测:自动解剖芯片 (AD-Chip) 结合延时显微技术,可在 3 天内对 20 种不同菌株的逾万个单酵母细胞进行自动化全寿命追踪。该芯片能够在整个衰老过程中对单细胞进行高分辨率荧光成像。


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▍Innovative Biochips产品列表


品名货号目录规格
1CellDish-60mmH2-SCD-5PKSingle-Cell Cloning and Analysis, Single-Cell Devices, Single-Cell PCR & Sequencing5 Petri Dishes
1CellDish-Glass BottomH6-SGB-5PKGlass Bottom Devices, Single-Cell Cloning and Analysis, Single-Cell Devices, Single-Cell PCR & Sequencing5 Petri Dishes
1CellPlate-miniP2-SCPM-5PKSingle-Cell Cloning and Analysis, Single-Cell Devices, Single-Cell PCR & Sequencing5 Plates
1CellPlate-Glass BottomP2-SCPM-5PKSingle-Cell Cloning and Analysis, Single-Cell Devices, Single-Cell PCR & Sequencing5 Plates
1CellPlate-96wellP2-SCPM-5PKSingle-Cell Cloning and Analysis, Single-Cell Devices, Single-Cell PCR & Sequencing5 Plates
1CellPlate-96Well Low EvaporationP2-SCPM-5PKSingle-Cell Cloning and Analysis, Single-Cell Devices, Single-Cell PCR & Sequencing5 Plates
1CellAssay-Chamber SlideH7-SCS-5PKGlass Bottom Devices, Single-Cell Cloning and Analysis5 Chamber Slides
1CellAssay Lysis KitK1-SCLS-KITSingle-Cell Cloning and Analysis, Single-Cell Kits, Single-Cell PCR & Sequencing-
1CellArray-Glass BottomH5-GBD-5PKGlass Bottom Devices, Single-Cell Devices, Single-Cell Imaging and Pairing5 Petri Dishes
Cell Pairing PlateP6-CPP-5PKCell Pairing Devices, Single-Cell Imaging and Pairing5 Plates
Gridded Polystyrene Dish for Super Resolution Imaging-70um WellsH11-SPD-10PKSingle-Cell Imaging and Pairing10 Petri Dishes
Gridded Polystyrene Dish for Super Resolution Imaging-50um WellsH12-SPD-10PKSingle-Cell Imaging and Pairing10 Petri Dishes
Gridded Polystyrene Dish for Super Resolution Imaging-30um WellsH13-SPD-10PKSingle-Cell Imaging and Pairing10 Petri Dishes
PicoWell Dish-72K WellsH8-PWD-10PKSingle-Cell Devices, Spheroid Cell Culture10 Petri Dishes
PicoWell Dish-160K WellsH9-PWD-10PKSingle-Cell Devices, Spheroid Cell Culture10 Petri Dishes
PicoWell Dish-300K WellsH10-PWD-10PKSingle-Cell Devices, Spheroid Cell Culture10 Petri Dishes
1CellAssay 3D Culture KitK2-SCTD-KITSingle-Cell Culture, Single-Cell Kits, Spheroid Cell Culture-
Million Microwell DeviceH4-MMD-5PKHigh-Throughput RNA-Sequencing, Single-Cell Devices, Single-Cell PCR & Sequencing5 MMDs
PicoWells In 6-Well PlateH8-PWP-5PKGlass Bottom Devices, High-Throughput RNA-Sequencing5 Plates
PicoWells In Chamber SlideH9-PCS-5PKGlass Bottom Devices, High-Throughput RNA-Sequencing5 Chamber Slides
Hole Array-1536S1-SHA-1536-10PKHigh-Density Cell Culture and Imaging, Standard Hole Array10 Plates
Hole Array-384S2-SHA-384-10PKHigh-Density Cell Culture and Imaging, Standard Hole Array10 Plates
Hole Array-6wellS3-SHA-900-10PKHigh-Density Cell Culture and Imaging, Standard Hole Array10 Plates
Hole Array-60mmS4-SHA-350-10PKHigh-Density Cell Culture and Imaging, Standard Hole Array10 Petri Dishes
Hole Array-Glass BottomS5-SHA-75-10PKHigh-Density Cell Culture and Imaging, Standard Hole Array10 Petri Dishes
Hole Array-SlideS6-SHA-240-10PKHigh-Density Cell Culture and Imaging, Standard Hole Array10 Slides
Hole Array-CoverslipS7-SHA-240-10PKHigh-Density Cell Culture and Imaging, Standard Hole Array10 Coverslips
Hole Array-ChamberS8-SHA-160-12PKHigh-Density Cell Culture and Imaging, Standard Hole Array12 Chamber Slides
Automated Dissection ChipA1-AD-5PK-1Yeast Aging Assays5 Chips
Automated Dissection Screening ChipA3-ADS-5PKYeast Aging Assays5 Chips



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荷兰Duchefa Biochemie B.V.公司作为DUCHEFA FARMA BV的基础上成立于1989年,而后者50多年来一直为世界各药厂和医院提供生化试剂以及药物原材料。1989年,身处在农业和花草业方面以及国际贸易有着悠久历史的荷兰,Duchefa公司成立了植物组织及细胞培养实验室,开始向世界提供各种高质量植物组培产品。十多年以来,这些产品已经广泛应用在世界各国一流大学的实验室研究,以及植物细胞组织相关的研发中。在Duchefa公司主要提供植物细胞和组织培养基、各种植物生长调节剂、抗生素、植物胶凝、酶作用底物、植物分子生物化学试剂以及种子病原体检测试剂,种类超过400种的试剂用于植物生物技术开发以及植物病理学研究。

Duchefa Biochemie bv offers a whole range of plant tissue culture media, biochemicals, containers, bioreactors and alot of other products needed for micro-propagation. All media are produced in our own laboratories and custom made media are produced for many customers.

 

主要产品类型:

ENZYMES

GELLING AGENTS

GROWTH REGULATORS

PHYTOPATHOLOGICA & MICROBIOLOGY

PLANT TISSUE CULTURE MEDIA

PTC CONTAINERS

REAGENTS & BIOCHEMICALS

UTENSILIA

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Dendritics.jpg

Dendritics公司主要关注人类树突状细胞,希望找到能够促使CD34+造血前体细胞转化为树突状细胞(在GM-CSF和TNF-alpha存在的情况下)的细胞因子。在1992-2005年间,大量的研究使得研究者对人类树突状细胞的产生、细胞通路、C-type凝集素受体的功能及Toll-like受体的活性有了更深的理解。

 

DENDRITICS was started in 2005 by former members of SCHERING PLOUGH Laboratory for Immunological Research (LIR) in Dardilly, France. From their long experience at LIR, the team members of DENDRITICS have gathered complementary scientific and technological knowledge in different areas of immunology. The initial focus of LIR was in the biology of B lymphocytes, elaboration of human monoclonal antibodies, and in cytokine discovery (IL-3, IL-4, IL-7, IL-10, IL-17, GM-CSF) together with our colleagues of DNAX Research Institute in Palo Alto, California.

 

Our interest in cytokines led to the finding that human dendritic cells (DCs) could be generated in vitro from CD34+ hematopoietic progenitors cultured in the presence of GM-CSF and TNF-alpha.

 

The period from 1992 to 2005 saw the specialization of LIR in DC biology and was fuelled by a large-scale effort to discover and study the function of genes specifically expressed by these cells. This program led to a number of findings that contributed in particular to understanding the heterogeneity of DCs, the pathways regulating DC migration, the function of C-type lectin receptors in DCs and the activity of Toll-like receptors in DCs. Many novel genes were discovered through screening of cDNA libraries or through monoclonal antibodies raised against DCs.

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